Table 4. Association Between sVCAM-1 and Ischemic Stroke in the Bruneck Studya.
Characteristic | Events, No. | Incidence Rate per 1000 Person-years (95% CI) | HR (95% CI) | P Value |
---|---|---|---|---|
All ischemic strokes | 101 | 5.8 (4.7-7.0) | 0.97 (0.78-1.20) | .75 |
AF-related ischemic stroke | 24 | 1.3 (0.9-2.0) | 1.54 (1.01-2.35) | .048 |
Non–AF-related ischemic stroke | 77 | 4.4 (3.5-5.5) | 0.85 (0.66-1.09) | .20 |
Abbreviations: AF, atrial fibrillation; HR, hazard ratio; sVCAM-1, soluble vascular cell adhesion molecule 1.
The sVCAM-1 level was treated as a continuous variable. Cox proportional hazard models were used to calculate hazard ratios associated with a 1-SD higher sVCAM-1 level. Models were adjusted for age (years), sex, smoking (0 vs 1), alcohol consumption (grams per day), hypertension (0 vs 1), loge N-terminal pro-B-type natriuretic peptide (picograms per milliliter), high-sensitivity cardiac troponin T level (undetectable vs tertiles of detectable), diabetes (0 vs 1), glomerular filtration rate (milliliters per minute), high-sensitivity C-reactive protein (milligrams per liter), and atherosclerosis (0 vs 1).