Table 1. Baseline Characteristics of Jackson Heart Study Participants Stratified by Statin Eligibility by ACC/AHA and USPSTF Guidelines.
| Characteristic | USPSTF Guidelines | P Value | ACC/AHA Guidelines | P Value | ||
|---|---|---|---|---|---|---|
| Statin Eligible (n = 1072) | Statin Ineligible (n = 1740) | Statin Eligible (n = 1404) | Statin Ineligible (n = 1408) | |||
| Age, mean (SD), y | 62.4 (7.6) | 51.0 (7.6) | <.001 | 60.9 (8.3) | 49.9 (6.9) | <.001 |
| Female, No. (%) | 612 (57.1) | 1225 (70.4) | <.001 | 812 (57.8) | 1025 (72.8) | <.001 |
| Male, No. (%) | 460 (42.9) | 515 (29.6) | <.001 | 592 (42.2) | 383 (27.2) | <.001 |
| BMI, mean (SD) | 31.7 (6.7) | 31.6 (7.3) | .80 | 31.7 (6.8) | 31.5 (7.3) | .59 |
| Current smoking, No. (%) | 182 (17.0) | 182 (10.5) | <.001 | 222 (15.8) | 142 (10.1) | <.001 |
| Hypertension, No. (%) | 839 (78.3) | 647 (37.2) | <.001 | 1002 (71.4) | 484 (34.4) | <.001 |
| Diabetes, No. (%) | 348 (32.5) | 86 (4.9) | <.001 | 416 (29.6) | 18 (1.3) | <.001 |
| Antihypertensive therapy, No. (%) | 723 (67.4) | 579 (33.3) | <.001 | 879 (62.6) | 423 (30.0) | <.001 |
| Total cholesterol, mean (SD), mg/dL | 215.8 (45.3) | 194.1 (32.8) | <.001 | 213.4 (41.8) | 191.4 (33.6) | <.001 |
| LDL-C | 141.8 (42.1) | 122.1 (30.5) | <.001 | 139.9 (38.3) | 119.4 (31.8) | <.001 |
| HDL-C | 50.4 (14.5) | 53.4 (14.5) | <.001 | 50.8 (14.1) | 53.7 (14.8) | <.001 |
| PCE risk score, median (IQR), % | 15.5 (11.9-21.7) | 4.0 (1.7-6.5) | <.001 | 12.9 (9.3-19.1) | 3.3 (1.3-5.2) | <.001 |
| Coronary artery calcium score, No. | 600 | 1143 | 817 | 926 | ||
| Mean (SD) | 220.3 (466.4) | 37.0 (140.5) | NA | 178.7 (413.2) | 30.8 (136.4) | NA |
| Median (IQR) | 37.6 (0-194.3) | 0 (0-4.7) | <.001 | 23.8 (0-138.2) | 0 (0-0) | <.001 |
| Score >0, No. (%) | 404 (67.3) | 328 (28.7) | <.001 | 507 (62.1) | 225 (24.3) | <.001 |
| Score >100, No. (%) | 213 (35.5) | 97 (8.5) | <.001 | 248 (30.4) | 62 (6.7) | <.001 |
| Abdominal aortic calcium score, No. | 599 | 1143 | 816 | 926 | ||
| Mean (SD) | 1218.8 (1621.4) | 332.2 (904.3) | NA | 1090.6 (1559.9) | 237.3 (746.8) | NA |
| Median (IQR) | 532.3 (66.6-1866.1) | 5.5 (0-173.7) | <.001 | 418.4 (40.9-1538.0) | 0 (0-108.7) | <.001 |
| Score >0, No. (%) | 512 (85.5) | 598 (52.3) | <.001 | 681 (83.5) | 429 (46.3) | <.001 |
Abbreviations: ACC/AHA, American College of Cardiology/American Heart Association; BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); HDL-C, high-density lipoprotein cholesterol; IQR, interquartile range; LDL-C, low-density lipoprotein cholesterol; NA, not applicable; PCE, Pooled Cohort Equation; USPSTF, US Preventive Services Task Force.