Figure 7.

MALAT1 down-modulation inhibits GBM tumor growth. Mice bearing intracranial U87-luc2 tumors were treated with scL-siMAL and/or TMZ as shown in (A). N = 5 mice per group. (B) Bioluminescence images (BLI) of the intracranial U87-luc2 tumor are shown from before (day 10) and after the treatments (day 21). Bioluminescence signals, shown in a color map, correlate with tumor sizes. Red color: stronger signal, Violet color: weaker signal. (C) Change in bioluminescence intensity of individual tumor was quantitated. (D) Bioluminescence intensities of tumors were plotted as a function of time. (E) Brain tumors were weighed at harvest on day 23. N = 4 to 5 tumors per group *P < 0.05, **P < 0.001.