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. 2018 Feb 16;19:22. doi: 10.1186/s13059-018-1397-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a Example of called aDMPs. Top: A significant aDMP in human samples (top left) but not in mouse samples (top right). Bottom: A significant aDMP in mouse samples (bottom right) but not in human samples (bottom left). Thick coloured boxes represent a genome-wide significance aDMP in either human (purple) or mouse (red). b A Venn diagram representing the overlap between called aDMPs in mouse and human. c A density plot of the negative log transformed gradients for those aDMPs in non-sequence conserved regions in either mouse (red) or human (purple). d A density plot of the negative log transformed gradients for those aDMPs in regions showing sequence conservation between mouse (red) and human (purple)