Table 3.
Typical examples of nVGDS for skin tissue repair and regeneration
| Chemical vector | Scaffold/matrices | Wound type | Animal/cell | DNA/RNA | References |
|---|---|---|---|---|---|
| TMC | Collagen–chitosan | Full-thickness burns | Porcine | pDNA-VEGF165 | [132] |
| TMC | Collagen–chitosan/silicone membrane | Excisional skin defect | Porcine/fibroblasts | siRNA TGF-b1 pathway | [133] |
| PEI | PLA/PCL | Full-thickness skin defect | NIH-3T3 cells/C57BL/6J mice | pDNA-KGF | [134] |
| PEI | Collagen scaffold with a copoly-mer P6YE5C | Full-thickness skin defect | Nude mice/NIH-3T3 | pVF1164-hVEGF165 | [135] |
| PEI | PELA scaffold | Subcutaneous implantation | SD rats/HUVEC | pDNA-VEGF and pDNA-bFGF | [136] |
| PEG | Collagen scaffold | Full thickness skin defect | Rat/fibroblast | microRNA (miR)-29B | [137] |
| PLL-g-PEG polymers | Fibrin hydrogels | Full-thickness excisional skin defect | Healthy or diabetic rats/COS-7 cells | pDNA-HIF-1α | [138] |
| DMAEMA/PAA (PH responsible) | Polyurethane (PUR) scaffold | Nonhealing skin wounds | Diabetic rats/human cervical cancer cells | siRNA silencing GAPDH gene | [139] |
| Lipofectamine™ 2000 | Collagen gels | Full-thickness burn | Rat/HaCaT cells | pDNA-EGF | [140] |
| None | None | Infected full-thickness burn | Human keratinocyte progenitor cell line (NIKS) | Plasmid-hCAP-18 | [142] |
| None | None | Full-thickness burn with sepsis | NIKS human keratinocyte cell line | Plasmid-hBD-3/mice | [143] |