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. 2018 Feb 15;17:82. doi: 10.1186/s12936-018-2225-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — CHI3L1 levels are elevated over hospitalization according to the severity of acute kidney injury. Line plots showing individual CHI3L1 trajectories for patients according to the severity KDIGO-defined acute kidney injury (AKI). CHI3L1 levels for in-hospital mortality are depicted in red. The line for the linear mixed effects model is shown in black. Time, nitric oxide treatment arm, and AKI stage were entered as fixed effects. In this model, AKI grade 1, 2 and 3 was associated with CHI3L1 concentrations 1.02, 1.3, and 2.5-fold higher than patients without AKI, over the course of the first 3 days of hospitalization (p < 0.0001)