Table 3.
Association between admission CHI3L1 levels and risk of death
| In-hospital mortality | All cause 6 month mortality | |||
|---|---|---|---|---|
| RR (95% CI) | p value | RR (95% CI) | p value | |
| Primary models | ||||
| iNO group | 0.72 (0.28, 1.90) | 0.512 | 0.85 (0.41, 1.76) | 0.670 |
| AKI | 2.61 (0.85, 8.00) | 0.094 | 1.28 (0.61, 2.68) | 0.521 |
| Log10CHI3L1 | 4.10 (1.32, 12.75) | 0.015 | 3.21 (1.47, 6.98) | 0.003 |
| Sensitivity analysis | ||||
| Model 1: children < 5 years of age LTFU dieda | ||||
| iNO group | – | – | 0.87 (0.52, 1.45) | 0.589 |
| AKI | – | – | 1.33 (0.76, 2.32) | 0.312 |
| Log10CHI3L1 | – | – | 2.13 (1.18, 3.84) | 0.012 |
| Model 2: children < 5 years of age LTFU survived | ||||
| iNO group | – | – | 0.78 (0.37, 1.65) | 0.513 |
| AKI | – | – | 1.29 (0.61, 2.75) | 0.505 |
| Log10CHI3L1 | – | – | 3.11 (1.38, 6.99) | 0.006 |
| Model 3: children < 5 years of age LTFU or > 5 years dieda | ||||
| iNO group | – | – | 0.76 (0.49, 1.17) | 0.213 |
| AKI | – | – | 1.21 (0.77, 1.90) | 0.419 |
| Log10CHI3L1 | – | – | 1.99 (1.22, 3.25) | 0.006 |
| Model 4: children < 5 years of age LTFU or > 5 years survived | ||||
| iNO group | – | – | 0.86 (0.40, 1.84) | 0.701 |
| AKI | – | – | 1.30 (0.60, 2.81) | 0.509 |
| Log10CHI3L1 | – | – | 3.10 (1.34, 7.16) | 0.008 |
Default model: generalized linear model with binomial family and log link
LFTU lost to follow up
aIn the event of failed convergence a Poisson model with robust standard errors was used