Skip to main content
. Author manuscript; available in PMC: 2018 Feb 16.
Published in final edited form as: Curr Med Chem. 2017;24(28):3104–3114. doi: 10.2174/0929867324666170407141955

Table 1.

List of antihypertensive (ACE, ARBs and diuretic) drugs in clinical trials on DR.

Trials Name Group DR risk factor References
EUCLID Trial
Lisinopril (ACE inhibitor) Insulin dependent 50% reduction #74
DIRECT Trial
Candesartan (AT1R blocker) Type 1 diabetes 18% (reduction) #75
Type 2 diabetes 34% (reduction) #76
RASS (5 year follow-up)
Enalapril (ACE inhibitor) Type 1 diabetes 65% (reduction) #77,78
Losartan (AT1R blocker) Type 1 diabetes 70% (reduction) #77,78
ABCD Trial
On blood pressure medications Hypertensive + Type 2 diabetes No progression of DR #79
ADVANCE Trial
Perindopril (ACE inhibitor)
+
Indapamide (antihypertensive/diuretic drug)		 Hypertensive + Diabetes Reduced cardiovascular mortality but no effect on retinopathy risk. #80

(EUCLID: The EURODIAB Controlled trial of Lisinopril in Insulin dependent Diabetes; DIRECTEUCLID: Diabetic Retinopathy Candesartan Trial; RASS: The Renin-Angiotensin System Study; ABCD: The Appropriate Blood Pressure Control in Diabetes; ADVANCE: The Action in Diabetes and Vascular Disease Controlled Evaluation).