Table 2.
Symptom endorsement rates (%) by comparison groups.
| All | FH neg. | FH pos. | χ2 | P | PRS low | PRS high | χ2 | P | AAO > = 28 | AAO < 28 | χ2 | P | No adv. | Adv. | χ2 | P | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | 5784 | 3907 | 1494 | 3909 | 1301 | 4149 | 1477 | 3511 | 1812 | ||||||||
| Appetite loss | 83.4 | 83.5 | 83.7 | 0.1 | 0.778 | 82.8 | 84.9 | 3.1 | 0.080 | 85.0 | 79.7 | 21.2 | 0.000 | 84.5 | 81.1 | 9.8 | 0.002 |
| Weight loss | 58.8 | 57.8 | 61.6 | 6.4 | 0.011 | 58.9 | 58.3 | 0.1 | 0.745 | 60.5 | 54.4 | 15.5 | 0.000 | 58.6 | 58.8 | 0.0 | 0.934 |
| Appetite gain | 9.5 | 9.1 | 10.2 | 1.2 | 0.266 | 10.2 | 7.1 | 10.0 | 0.002 | 8.4 | 12.3 | 18.7 | 0.000 | 7.8 | 13.0 | 36.3 | 0.000 |
| Weight gain | 6.7 | 6.2 | 7.3 | 1.9 | 0.163 | 6.9 | 5.5 | 2.4 | 0.124 | 6.1 | 8.5 | 9.5 | 0.002 | 5.5 | 9.1 | 24.7 | 0.000 |
| Insomnia | 92.3 | 92.5 | 92.2 | 0.0 | 0.877 | 92.5 | 91.6 | 0.5 | 0.469 | 93.4 | 90.0 | 17.5 | 0.000 | 93.3 | 91.1 | 8.8 | 0.003 |
| Hypersomnia | 13.1 | 11.7 | 16.4 | 20.8 | 0.000 | 12.7 | 13.5 | 0.4 | 0.541 | 11.6 | 17.3 | 30.0 | 0.000 | 11.7 | 16.2 | 19.8 | 0.000 |
| Psychomotor retardation | 76.0 | 76.0 | 77.2 | 0.9 | 0.346 | 75.3 | 77.8 | 3.1 | 0.077 | 75.9 | 76.5 | 0.2 | 0.642 | 76.2 | 77.0 | 0.2 | 0.627 |
| Psychomotor agitation | 72.5 | 72.4 | 74.0 | 1.5 | 0.221 | 73.2 | 71.6 | 1.0 | 0.321 | 73.4 | 70.3 | 5.0 | 0.025 | 73.2 | 71.6 | 1.6 | 0.201 |
| Fatigue | 93.4 | 92.9 | 95.2 | 10.8 | 0.001 | 93.2 | 94.0 | 0.9 | 0.344 | 94.0 | 91.8 | 7.5 | 0.006 | 93.5 | 93.1 | 0.5 | 0.489 |
| Worthlessness | 90.1 | 89.5 | 92.1 | 8.6 | 0.003 | 90.0 | 89.4 | 0.4 | 0.552 | 89.3 | 92.3 | 11.0 | 0.001 | 89.6 | 92.1 | 8.2 | 0.004 |
| Reduced concentration | 97.5 | 97.4 | 98.2 | 3.8 | 0.051 | 97.7 | 97.6 | 0.0 | 0.995 | 97.7 | 97.6 | 0.0 | 0.950 | 97.7 | 98.1 | 0.3 | 0.558 |
| Suicidal ideation | 76.2 | 75.9 | 77.3 | 1.3 | 0.253 | 76.1 | 75.1 | 0.5 | 0.500 | 75.9 | 77.5 | 1.6 | 0.203 | 74.1 | 80.0 | 21.1 | 0.000 |
| Lost interest in (nearly) all activities | 78.4 | 78.9 | 78.8 | 0.0 | 0.855 | 78.4 | 80.0 | 0.7 | 0.394 | 79.8 | 76.1 | 8.2 | 0.004 | 80.0 | 76.8 | 7.4 | 0.006 |
| Decreased self esteem | 84.2 | 83.9 | 85.3 | 1.6 | 0.208 | 84.8 | 82.8 | 2.8 | 0.093 | 83.5 | 86.5 | 7.6 | 0.006 | 83.5 | 85.5 | 3.4 | 0.063 |
| Decreased self confidence | 86.1 | 86.3 | 86.9 | 0.5 | 0.489 | 86.2 | 85.2 | 0.9 | 0.351 | 85.4 | 88.1 | 7.0 | 0.008 | 86.0 | 86.4 | 0.1 | 0.754 |
| Depression different from grief | 93.0 | 92.9 | 93.6 | 0.6 | 0.425 | 93.0 | 93.3 | 0.1 | 0.756 | 92.6 | 94.0 | 2.6 | 0.105 | 93.3 | 92.4 | 1.2 | 0.280 |
| Diurnal variation | 62.0 | 60.6 | 65.9 | 13.1 | 0.000 | 61.8 | 61.6 | 0.0 | 0.842 | 62.2 | 61.7 | 0.1 | 0.773 | 63.4 | 60.1 | 5.4 | 0.020 |
| Decreased libido | 88.8 | 88.3 | 91.0 | 8.0 | 0.005 | 88.4 | 88.9 | 0.2 | 0.694 | 89.8 | 86.1 | 14.2 | 0.000 | 89.5 | 88.2 | 1.7 | 0.192 |
| Loss of ability to enjoy good things | 86.2 | 86.1 | 87.2 | 1.1 | 0.304 | 86.5 | 85.1 | 1.5 | 0.221 | 87.0 | 83.6 | 10.3 | 0.001 | 86.7 | 84.5 | 4.4 | 0.035 |
| Irritability or anger | 74.7 | 73.4 | 77.1 | 7.9 | 0.005 | 75.2 | 71.9 | 5.5 | 0.019 | 73.9 | 76.5 | 3.7 | 0.054 | 72.6 | 79.0 | 25.7 | 0.000 |
| Hopeless | 80.6 | 79.5 | 83.4 | 10.3 | 0.001 | 80.0 | 81.6 | 1.3 | 0.263 | 78.9 | 85.1 | 26.2 | 0.000 | 78.6 | 84.2 | 23.2 | 0.000 |
| Cry a lot | 67.4 | 66.6 | 69.4 | 3.9 | 0.048 | 67.8 | 67.0 | 0.3 | 0.597 | 66.2 | 71.2 | 11.9 | 0.001 | 65.7 | 71.2 | 16.2 | 0.000 |
| Helpless | 89.2 | 88.2 | 92.2 | 18.0 | 0.000 | 89.1 | 89.4 | 0.0 | 0.841 | 88.5 | 91.6 | 11.0 | 0.001 | 87.8 | 92.6 | 28.3 | 0.000 |
| Nervous, jittery, anxious | 89.2 | 87.7 | 93.4 | 36.3 | 0.000 | 89.5 | 88.3 | 1.4 | 0.245 | 88.8 | 90.6 | 3.5 | 0.062 | 88.6 | 90.5 | 4.3 | 0.039 |
| Average symptom endorsementa | 72.9 | 72.4 | 74.6 | −6.2 | 0.000 | 72.9 | 72.6 | 0.9 | 0.348 | 72.8 | 73.3 | −1.3 | 0.192 | 72.6 | 73.9 | −3.8 | 0.000 |
AAO, age at onset; Adv., adversity; FH, family history; PRS, polygenic risk score; χ2, chi-squared; P, P-value. Endorsement rates are expressed in percentages. In bold: P-values < 0.0005 (Bonferroni–corrected).
a
Statistic for average symptom endorsement is t-test.