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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Biomaterials. 2018 Jan 8;160:24–36. doi: 10.1016/j.biomaterials.2018.01.012

Figure 5. Effect of tyrosinase-mediated gel stiffening on enzyme-mediated degradation.

Figure 5

(A) Comparison of modulus changes in hydrogels modularly crosslinked by GelNB or GelNB-HPA with PEG4SH or THA. Gel moduli were characterized prior to and after treating with 1 kU/mL TYR for 6 hours (***p < 0.001). (B) Mass loss profiles of Gel/HA (soft) or GelHPA/HA (TYR-stiffened) hydrogels treated with collagenase (40 U/mL). (C) Mass loss profiles of Gel/HA (soft) or GelHPA/HA (TYR-stiffened) hydrogels treated with hyaluronidase (300 U/mL). Hydrogels in (B) and (C) were formed by 7% GelNB or GelNB-HPA with 0.7% THA (N=3, Mean ± SEM).