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. Author manuscript; available in PMC: 2018 Feb 16.
Published in final edited form as: Eur J Pharmacol. 2016 Apr 13;785:24–35. doi: 10.1016/j.ejphar.2016.04.024

Fig. 3. Crystal structures of TLR2-TLR1/6 heterodimers induced by binding of triacyl and diacyl lipopeptides.

Fig. 3

(a) Lipid-binding pocket in the TLR2-TLR1-Pam3CSK4 complex. The structures of the TLRs are dissected to reveal the shape of the lipid pocket. (b) Lipid-binding pocket in the TLR2-TLR6-Pam2CSK4 complex. The putative lipid channel of TLR6 is blocked by phenylalanines F343 and F365. (c) Summary of the lipopeptide patterns recognized by the TLR1-TLR2 and TLR2-TLR6 heterodimers. (Kang and Lee, 2011).