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. 2018 Feb;59(2):858–869. doi: 10.1167/iovs.17-23034

Figure 3.

Figure 3

The Arg-Gln dipeptide administered by gavage promotes retinal blood vessel regrowth in the OIR model. (A–C) Retinal flat mounts from FITC-dextran–perfused mice. (A) Representative retinal flat mount from mouse pup undergoing OIR model and treated with vehicle given by gavage (n = 10). (B) Representative retinal flat mount from mouse pup undergoing OIR model and treated with the Arg-Gln dipeptide (n = 7). (C) Representative retinal flat mount from healthy control mouse maintained at room air and euthanized at P17 (n = 6). (D) An example of how vascular density is determined. The actual grid was superimposed onto each image. The intersections of the grid with the dextran-labeled vasculature were shown as yellow dots. (E) Graphical summary of all the vascular density data from all three cohorts of mice. *Indicates that P values compared to vehicle are < 0.05. Scale bar: 0.2 mm.