Figure 7.

Schematic representation of impact of dipeptide treatment on OIR mouse model. Pups undergoing the OIR model showed increased levels of proteins associated with apoptosis, autophagy and permeability, and reductions in proteins that are needed for RPE cell adherence compared to pups maintained in room air. Gavage treatment of OIR mice with the Arg-Gln dipeptide stimulates retinal anti-apoptosis proteins and returned autophagy proteins and proteins promoting RPE cell adhesion toward levels observed in normoxia.