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. 2017 Dec 7;32(2):174–190. doi: 10.1177/0269881117743484

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 8. — Analyses of apoptotic pathway in the hippocampus of Tc1 mice injected with amyloid-β [25-35] (Aβ_25-35) peptide. Wildtype (WT) or Tc1 mice were administered intracerebroventricular (i.c.v.) injections with scrambled peptide (Sc.Aβ) or Aβ_25-35 peptide (9 nmol) and sacrificed 10 days after injection. The levels of pro-apoptotic proteins, Bax (a) and Bim (b), and anti-apoptotic proteins, Bcl-W (c) and Bcl-XL (d), were assessed by Western blot in the hippocampal protein lysates. Typical blots are shown in (e). The number of animals per group is indicated below the columns. Two-way analysis of variance (ANOVA): F_(1,35)=8.37, p<0.01 for the genotype, F_(1,35)=14.1, p<0.001 for the treatment, F_(1,35)=1.03, p>0.05 for the interaction in (a); F_(1,36)=34.8, p<0.0001 for the genotype, F_(1,36)=10.1, p<0.01 for the treatment, F_(1,36)=0.559, p>0.05 for the interaction in (b); F_(1,33)=6.28, p<0.05 for the genotype, F_(1,33)=1.22, p>0.05 for the treatment, F_(1,37)=7.71, p<0.01 for the interaction in (c); F_(1,30)=0.463, p>0.05 for the genotype, F_(1,30)=1.47, p>0.05 for the treatment, F_(1,30)=1.48, p>0.05 for the interaction in (d); *p<0.05; **p<0.01 vs same genotype Sc.Aβ-treated mice; #p<0.05; ##p 0.01; ###p<0.001 vs same treatment WT mice; Bonferroni’s test.