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. 2018 Jan 2;17(1):9–10. doi: 10.1080/15384101.2017.1389197

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Figure 1. — Models past and present of the drivers of global transcriptional oscillations during the eukaryotic cell cycle in yeast. The CDK-APC oscillator controls a global transcriptional oscillator (top); a global transcriptional oscillator directly regulates oscillations in global transcription and CDK1-cyclin B activity, while CDK1-APC oscillations also impact global transcriptional oscillations (center); or, a global transcriptional oscillator drives periodic transcription and is influenced by signal amplification through CDK activity, and vice versa (bottom). All enclosed components indicated are control elements; components indicated by arrowheads are outputs.