Figure 4.

TPL inhibits EPT of T-LBL cells. Jurkat cells were treated with different concentrations of TPL (20, 60, and 80 nM). (A–C) Relative mRNA level of Snail, Slug, and Twist in different groups was measured by qRT-PCR. (D) Relative protein level of E-cadherin and integrin αVβ6 in different groups was measured by Western blot. The bars show mean ± SD of three independent experiments. *P<0.05, **P<0.01 compared with control group.

Abbreviations: T-LBL, T-cell lymphoblastic lymphoma; EPT, epithelial–mesenchymal transition; TPL, triptolide; qRT-PCR, quantitative real-time polymerase chain reaction; SD, standard deviation.