Figure 5.

TPL inhibits PI3K/AKT/mTOR signaling pathway in T-LBL cells.

Notes: Jurkat cells were treated with different concentrations of TPL (20, 60, and 80 nM). (A) Relative protein level of p-PI3K, p-Akt, and mTOR in different groups was measured by Western blot. (B) The expression of AKT in different groups was detected by immunofluorescence. The bars show mean ± SD of three independent experiments. *P<0.05 compared with control group.

Abbreviations: T-LBL, T-cell lymphoblastic lymphoma; TPL, triptolide; SD, standard deviation.