Table 2.
Mean pharmacokinetic parameters of amikacin in Groups A and B
| Values (mean±SD) | Group A (15 mg/kg) | Group B (25 mg/kg) | P-value |
|---|---|---|---|
| VD Day 3 (L/kg) | 0.54±0.19 | 0.53±0.25 | 0.279 |
| VD Day 7 (L/kg) | 0.45±0.09 | 0.49±0.18 | 0.549 |
| Amikacin dose (mg/d) | 927±180 | 1423±277 | 0.000 |
| Cmin Day 3 (µg/mL) | 3.26±2.13 | 5.22±2.87 | 0.035 |
| Cmax Day 3 (µg/mL) | 30.41±11.09 | 52.28±16.11 | 0.000 |
| Cmin Day 7 (µg/mL) | 3.20±2.92 | 9.28±5.62 | 0.002 |
| Cmax Day 7 (µg/mL) | 33.05±7.31 | 60.01±17.64 | 0.001 |
| t½ Day 3 (hour) | 7.11±2.46 | 5.51±0.84 | 0.568 |
| t½ Day 7 (hour) | 6.55±2.46 | 9.04±2.60 | 0.018 |
| Cl amikacin Day 3 (mL/min) | 55±35 | 56±22 | 0.91 |
| Cl amikacin Day 7 (mL/min) | 51±32 | 47±26 | 0.72 |
Abbreviations: Cl, clearance; t½, half-life; VD, volume of distribution.