2. Epidemiology of malaria and major vector of the study region.

Study	Intervention	Design	Transmission intensity1,2	Region	Main malaria vectors	Biting times	Efficacy of the intervention at repelling Anophelines tested at baseline? (V/N)
Chen‐Hussey 2013	Topical repellent	cRCT	Hypoendemic 0.83% P. falciparum 0.4% P. vivax Measured through active case detection	South East Asia ‐ Laos	Anopheles dirus An. minimus An. maculatus	From 18:00 to 2:00 with peak biting time from 21.00 to 02.00.	No
Hill 2007	Topical repellent	cRCT	Hypoendemic 0.31% P. falciparum Measured through active case detection	South America: Bolivian Amazon Region	An. darlingi	Peak biting activity between 8 p.m. and 10 p.m.	Yes Moore 2002
Hill 2014	Spatial repellent	cRCT	Hypoendemic 0.06% P. falciparum 0.28% P. vivax Measured through active case detection	South East Asia: Yunnan Province of China	An. sinensis An. minimus An. kochi An. splendidus An barbirostris An. vagus An. jeyporiensis An. annularis An. philippinsis An. tessallatus An. maculatus An. barbumbrosus An. dirus An culicifacies	Given the diversity of vectors in the area the biting activity occurs from early evening extending to later in the night.	Yes
McGready 2001	Topical repellent	RCT	Mesoendemic 11.4% P. falciparum 11.8% P. vivax Measured through active case detection	South East Asia: Thailand	Not reported	Not reported	No
Rowland 1999	Insecticide treated clothing	cRCT	Holoendemic 20.7% P. falciparum 17.6% P. vivax Measured through passive case detection	North Western Pakistan	An. nigerrimus An. subpictus An. stephensi	Not reported	Yes
Rowland 2004	Topical repellent	cRCT	Mesoendemic 8.9% P. falciparum 11.7% P. vivax Measured through passive case detection	Asia: Pakistan	An. culicifacies An. stephensi An. nigerrimus An. pulcherrimus	Mosquito biting starts after dusk, peaks around 9 p.m. to 11 p.m. then declines gradually through the night.	Yes
Sangoro 2014a	Topical repellent	cRCT	Mesoendemic 6.22% P. falciparum Measured through passive case detection	East Africa: Tanzania	An gambiae s.s. An arabiensis	Biting activity starts early evening and continues into the later hours of the night.	Yes Sangoro 2014c
Sluydts 2016	Topical repellent	cRCT	Hypoendemic 1.33% P. falciparum 1.85% P. vivax Measured through active case detection	Southeast Asia: Cambodia	An. dirus s.s. An. maculatus An barbirostris An. minimus s.s. An. sawadwongporni An aconitus	Early evening biting was common.	Yes Van Roey 2014
Soto 1995	Insecticide‐treated clothing	RCT	Mesoendemic for P.vivax and Hypoenemic for P. falciparum 3.4% P. falciparum 10.4% P. vivax Measured through passive case detection	South America: Colombia	Unclear	Not reported	No
Syafruddin 2014	Spatial repellent	cRCT	Holoendemic for Plasmodium spp. 70.1% Plasmodium spp. Measured through passive case detection	Asia: Indonesia	An. sundaicus An. subpictus s.l. An. indefinitus An. vagus An. barbirostris An. annularis An. maculatus An. aconitus An. kochi An. tessellatus	Early evening biting was common with peaks between 18:00 and 20:00 continuing throughout the night. The high diversity of vectors also reflected diverse biting patterns.	Yes Barbara 2011

¹Transmission intensity: holo‐endemic: malaria prevalence > 15%; meso‐endemic: malaria prevalence 5% to 15%; and hypo‐endemic: malaria prevalence < 5%.
 ²Calculated from prevalence in the control group.