Table 2.
Most common grade ≥3 toxicities and cause of treatment-related deaths
| R-CHOP-21 (N=301) |
R-CHOP-14 (N=303) |
|||
|---|---|---|---|---|
| Any grade | Grade ≥3 | Any grade | Grade ≥3 | |
| All toxicities | 292 (97%) | 216 (72%) | 299 (99%) | 182 (60%) |
| Neutropenia | 224 (74%) | 185 (61%) | 138 (46%) | 109 (36%) |
| Thrombocytopenia | 73 (24%) | 22 (7%) | 112 (37%) | 37 (12%) |
| Anemia | 60 (20%) | 6 (2%) | 95 (31%) | 14 (5%) |
| Infection | 145 (48%) | 71 (24%) | 146 (48%) | 71 (23%) |
| Fever | 70 (23%) | 16 (5%) | 56 (18%) | 16 (5%) |
| Mucositis | 143 (48%) | 4 (1%) | 167 (55%) | 8 (3%) |
| Nausea | 188 (62%) | 7 (2%) | 151 (50%) | 12 (4%) |
| Vomiting | 98 (33%) | 7 (2%) | 82 (27%) | 9 (3%) |
| Diarrhoea | 109 (36%) | 12 (4%) | 113 (37%) | 16 (5%) |
| Constipation | 185 (61%) | 7 (2%) | 160 (53%) | 8 (3%) |
| Neurological | 167 (55%) | 23 (8%) | 183 (60%) | 36 (12%) |
| Fatigue | 240 (80%) | 31 (10%) | 252 (83%) | 40 (13%) |
| Bone pain | 68 (23%) | 7 (2%) | 102 (34%) | 6 (2%) |
| Cardiac | 29 (10%) | 2 (1%) | 29 (10%) | 9 (3%) |
Treatment-related deaths: 3 in R-CHOP-21: 2 nonneutropenic sepsis and 1 neutropenic sepsis; and 7 in R-CHOP-14: 2 nonneutropenic sepsis, 1 neutropenic sepsis, 1 renal failure and 3 not specified.