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. 2018 Feb 16;13(2):e0191581. doi: 10.1371/journal.pone.0191581

Fig 5. Association of local-regional recurrence and disease specific survival with HPV16 E2 disruption in the oropharynx.

Fig 5

(A) Samples with an intact E2 gene (broken black line) have a lower incidence of local regional recurrence than oropharyngeal cases with a disrupted E2 gene (solid black line) (Mantel-Cox test p = 0.04). (B) Samples with an intact E2 gene (broken black line) have better disease specific survival than oropharyngeal cases with a disrupted E2 gene (solid black line) (Mantel-Cox test p = 0.03). (C and D) Samples were separated into high (broken black) or low (solid black) expression of viral genes based on median cutoff using derived (2maxΔCT- ΔCT) qRT-PCR results compared to GAPDH for: (C) HPV16 E7 (median = 1.69 2maxΔCT- ΔCT; Mantel-Cox test p = 0.004), and (D) HPV16 E6 (median = 1.23 2maxΔCT- ΔCT; Mantel-Cox test p = 0.006).