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. Author manuscript; available in PMC: 2018 Feb 16.
Published in final edited form as: Prostate. 2016 Jul 12;76(14):1312–1325. doi: 10.1002/pros.23221

Table 1. Up Regulated Genes in MET-HR PCa and Brain Compared in silico.

# Genes (of 274) p-value
Biological Processes

 Anatomical structure development 74 1.84e-05
 System development 70 1.86e-05
 Nervous system development 54 3.85e-12
 Central nervous system development 25 5.92e-06
 Transmission of nerve impulse 23 2.10e-05
 Synaptic transmission 21 2.61e-05
 Neuron projection development 19 2.10e-05
 Cell part morphogenesis 18 2.10e-05
 Cell morphogenesis involved in neuron differentiation 17 2.72e-05
 Neuron projection morphogenesis 17 2.72e-05

Molecular Function

 Protein binding 164 6.59e-05
 Ribonucleotide binding 52 7.60e-03
 Purine ribonucleotide binding 52 7.60e-03
 Kinase activity 27 7.60e-03
 Cytoskeletal protein binding 21 2.00e-03
 Protein tyrosine kinase activity 20 7.60e-03
 GTPase activity 15 1.20e-03
 Protein complex binding 12 2.00e-03
 Tubulin binding 7 7.60e-03
 Brain-specific angiogenesis inhibitor activity 3 7.60e-03

Cellular Component

 Cytoplasm 152 3.66e-07
 Cytoskeleton 40 5.00e-04
 Cell traction 37 2.82e-05
 Cell projection 29 2.38e-05
 Synapse 25 3.83e-08
 Neuron projection 22 4.85e-07
 Synapse 18 2.66e-06
 Axon 13 1.76e-05
 Dendrite 12 2.00e-05
 Synaptosome 11 1.41e-06