Table 2.
Variables Predicting Survival in Patients With Chronic ILD
| Characteristic | Progression-Free Survival (Within 1st y of Diagnosis) |
Transplant-Free Survival (Within 10 y of Diagnosis) |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | |
| Univariate Cox regression | ||||||
| Phenotypic clustera | ||||||
| Cluster 1 | 2.78 | 1.48-5.21 | .001 | 1.57 | 0.97-2.56 | .067 |
| Cluster 3 | 2.25 | 1.20-4.20 | .011 | 3.17 | 2.05-4.88 | < .001 |
| Cluster 4 | 4.31 | 2.31-8.03 | < .001 | 4.31 | 2.73-6.82 | < .001 |
| Diagnosis categoryb | ||||||
| CHP | 1.59 | 0.93-2.72 | .089 | 1.32 | 0.81-2.14 | .259 |
| IPAF | 1.96 | 1.19-3.24 | .009 | 2.32 | 1.53-3.51 | < .001 |
| IPF | 2.47 | 1.57-3.87 | < .001 | 3.80 | 2.65-5.46 | < .001 |
| GAP-ILD score | 1.23 | 1.13-1.33 | < .001 | 1.62 | 1.50-1.74 | < .001 |
| Multivariable Cox regressionc | ||||||
| Phenotypic clustera | ||||||
| Cluster 1 | 3.06 | 1.63-5.76 | .001 | 1.88 | 1.16-3.06 | .011 |
| Cluster 3 | 2.18 | 1.15-4.12 | .017 | 2.61 | 1.68-4.08 | < .001 |
| Cluster 4 | 3.64 | 1.94-6.84 | < .001 | 3.14 | 1.97-4.99 | < .001 |
| GAP-ILD score | 1.22 | 1.12-1.33 | < .001 | 1.57 | 1.46-1.69 | < .001 |
GAP = gender-age-physiology; HR = hazard ratio. See Table 1 legend for expansion of other abbreviations.
a
Reference category: Cluster 2.
b
Reference category: CTD-ILD.
c
n = 727; adjusted for phenotypic cluster, sex, age, FVC, diffusing capacity of the lungs for carbon monoxide, ILD subtype, and immunosuppressive therapy.