Figure 1. Changes in incidence of Merkel cell carcinoma (MCC) as compared to all solid tumors and melanoma, 2000–2013.
Data were extracted from the SEER-18 database, which captures 28% of the US population. A) US annual incidence rate of Merkel cell carcinoma The US annual incidence rate, age and sex adjusted to the 2000 US standard population (cases per 100,000 persons per year). Bars represent 95% confidence intervals. B) Cases reported to SEER with year 2000 as reference. The change in number of cases reported to SEER-18 (which reflects incidence rate and number of persons at risk in SEER catchment area) are shown, normalized to year 2000. The total number of solid tumors reported (blue squares) increased by 15% between 2000 and 2013, as compared 57 percent for melanoma (purple triangles), and 95% for MCC (green circles).