. Author manuscript; available in PMC: 2019 Mar 1.

Published in final edited form as: Wiley Interdiscip Rev RNA. 2017 Dec 27;9(2):10.1002/wrna.1459. doi: 10.1002/wrna.1459

Table 2.

Contribution of RNA binding proteins to diabetes pathogenesis.

RBPs	RBP target RNA(s) affected in diabetes	Diabetic complication(s)	Experimental Model(s)
LIN28A	Let7 microRNA family	Diabetic nephropathy and cardiac complications	Db/Db T2D mouse kidney and STZ T1D mouse kidney and heart
RBFOX2	FXR1, MEF2A, global alternatively spliced transcripts	Diabetic cardiac complications	STZ T1D mouse and human T2D patient heart
FTO	Global changes in A⁶ methylated transcripts	Unknown	Human T2D patient and STZ T1D rat peripheral blood
IGF2BP2	*LAMB2*	Diabetic nephropathy	STZ T1D mouse kidney
eIF4E	VEGF and genome wide transcripts	Diabetic myopathy, retinopathy, and cardiac complications	Alloxan induced T1D rat skeletal muscle and heart, STZ T1D rat retina, STZ T1D mouse and Akita T1D mouse liver and retina
CELF1	Global alternatively spliced transcripts	Diabetic myopathy and cardiac complications	NOD T1D mouse skeletal muscle and STZ T1D mouse heart
HuR	**VEGF, CTGF, TGFB1, SNAI1, FOS, and NOD2**	Vascular disease, diabetic nephropathy, retinopathy, and cardiac complications	Human diabetic patient heart and kidney biopsies, human T2D patient kidney biopsies, human patient vascular tissue, and STZ T1D rat kidney and retina