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. Author manuscript; available in PMC: 2018 Feb 17.
Published in final edited form as: Hepatol Int. 2018 Jan 3;12(1):6–16. doi: 10.1007/s12072-017-9838-6

Fig. 4.

Fig. 4

Lipotoxic in vitro model comparing obeticholic acid and a TGFβR inhibitor (LY2109761). The effect of obeticholic acid (OCA, dotted line) alone, a TGFβR inhibitor (LY2109761, dashed line) alone, or a combination of both treatments (solid line) were evaluated on key signaling pathways associated with NASH in the Feaver et al. lipotoxic in vitro model [23]. The axes represent the average gene pathway fold change response relative to the lipotoxic vehicle (VEH) response (gray, set to equal 1) and a healthy control response (light gray, set to equal 0)