Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Two-component system for autophosphorylation of a transmembrane histidine kinase (HK). A sensor perceives an extracellular stimulus. The substrate for the His kinase is the response regulator, which becomes phosphorylated on a specific Asp residue. In bacteria, the response regulator generally has a common domain with at least two Asp and one Lys residue 51. HK receptors are homodimeric proteins, and both trans and cis phosphorylations have been reported.
