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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: Cancer Res. 2017 Dec 19;78(4):1044–1057. doi: 10.1158/0008-5472.CAN-17-1904

Figure 5. STING induction and mitochondrial priming in erlotinib DTP cells.

Figure 5

A) Immunobloting analysis of STING in parental or erlotinib DTP PC9 cells transduced with indicated sgRNA. B, C) qRT-PCR of IL6 UFM1 knockout PC9 cells or control PC9 cells. D) Immunobloting analysis of STING in PC9 cells after the incubation with 300 ng/ml of tunicamycin for 24 hr. E) UFM1 or UFSP2 deleted PC9 cells and control PC9 cells were pre-treated with Erlotinib or DMSO for 48 hr. Pre-treatment with ER stress inducer tunicamycin or brefeldin A could attenuate the enhance effect by for following 100 nM THZ1 treatment. F) BH3 profiling revealing alteration of mitochondrial permeability following incubation with the indicated BH3 peptides.