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The role of TRPA1 in IL-8 cytokine secretion by cdPM (A; 12.5 μg/cm2 or 50 μg/mL) and PAHs (B; 12.5 and 25 μg/cm2 or 50 and 100 μg/mL). Cells were treated and assayed as in Fig. 2 in the presence and absence of the TRPA1 antagonist HC-030031 (25 μM). *Indicates statistical significance (*p<0.05; **p<0.005) relative to the control. #Indicates difference (p<0.05) relative to either RD or AD groups. Solid columns indicate cdPM from the FFB, and hatched columns indicate reference diesel.
