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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Clin Cancer Res. 2017 Nov 27;24(4):858–869. doi: 10.1158/1078-0432.CCR-17-0345

Figure 5.

Figure 5

Radiation induces survivin expression. (a) Upper: Effect of RT on survivin expression in PCI-15A cells at the indicated time points after RT (4 or 8 Gy). Lower: cells were pretreated with honokiol (5µg/ml for 24 h) followed by 4 Gy RT for 24 or 48 h. (b) Expression of survivin and other indicated proteins in PCI-15A parental and radioresistant cells (PCI-15A-RR) (left). The radiosensitivity was measured as SF2 (upper). (c) Honokiol downregulates survivin expression and inhibits the EGFR-STAT3 signaling pathway in PCI-15A-RR cells. Cells were treated with honokiol (5µg/ml) for 24 and 48 h. (d) PCI-15A-RR cells were treated with RT (2Gy) or honokiol (5µg/ml) alone or in combination then clonogenic assay was performed. All experiments were repeated three times, and representative data are presented.