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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Blood Rev. 2017 Aug 16;32(1):61–70. doi: 10.1016/j.blre.2017.08.008

Figure 4. Transcriptional regulation of miR-199a2 located in the intron of DNM3os gene by PPARα transcription factor and its pharmacological agonist Fenofibrate.

Figure 4

miR-199a2, which targets HIF-1α mRNA, is localized in an intron of DNM3os. Transcription factor, PPARα, which regulates DNM3os transcription concordantly regulates miR-199a2 expression as miR-199a2 is located in the DNM3os transcription unit. In the schematic, Fenofibrate, a PPARα agonist, augments the transcription of DNM3os and miR-199a2. As a result of increased expression of miR-199a2, there is a decrease in HIF-1α levels and concomitantly of ET-1, indicating therapeutic potential of Fenofibrate in PH. Adapted and modified (73).