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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Blood Rev. 2017 Aug 16;32(1):61–70. doi: 10.1016/j.blre.2017.08.008

Figure 6. Transcriptional regulation of miRNAs targeting HIF-1α, ET-1, PAI-1 and PlGF mRNAs.

Figure 6

PlGF activates HIF-1α and upregulates expression of ET-1 and PAI-1. Fenofibrate activates PPARα sites located in host genes DNM3os and SKA2. As a result, there is increased expression of miRs, which target PlGF, HIF-1α and ET-1 mRNAs, thus attenuating their expression in cells and tissues. miR-30c and miR-301a target PAI-1 mRNA expression; the latter is located within and intron of its SKA2 host gene. PAX5 transcription factor regulates transcription of MICAL3 host gene wherein miR-648 is located. miR-648 targets directly the 3′UTR of ET-1 mRNA.