Table 1.
Description of the two SNAP groups.
| SNAP/L− | SNAP/L+ | A- CN group | |
|---|---|---|---|
| Number (%) | 14 (25.9%) | 40 (74.1%) | 76 |
| Age (years) | 71.6 (7.6) | 74.0 (6.8) | 72.4 (6.0) |
| Gender (% men) | 12 (85.7%)a*,b* | 23 (57.5%) | 45 (59.2%) |
| Education (years) | 17.7 (2.0)a* | 16.3 (2.6) | 16.9 (2.6) |
| APOE-ɛ4 (%) | 6 (42.9)a,b | 6 (15.0) | 13 (17.1) |
| HV (mL) | 1769 (210)b | 1743 (249)c | 2126 (230) |
| HV rate (%/year) | 1.02 (2.27)a,b | −2.90 (2.07)c | −1.31 (1.66) |
| Follow up time MRI (days) | 317 (95) | 330 (89) | 304 (96) |
| FDG-PET◊ | −0.14 (1.12) | −0.39 (0.89)c | 0.00 (1.00) |
| SPARE-AD score | −0.65 (1.00)b | −0.41 (1.00)c | −1.34 (0.46) |
| Florbetapir (SUVR) | 1.02 (0.04) | 1.00 (0.06) | 1.01 (0.05) |
| CSF Aβ pg/mL | 207 (45)b | 205 (40)c | 236 (27) |
| WMH◊ | −0.10 (1.22)a | −0.86 (0.89)c | 0.00 (1.00) |
| MMSE score | 27.4 (1.7)a,b | 28.5 (1.5)c | 29.2 (1.1) |
| Delayed memory at baseline◊ | −1.22 (1.02)b | −1.11 (1.15)c | 0.00 (1.00) |
| TMT-B◊ | −0.78 (1.04)b | −0.91 (0.78)c | 0.00 (1.00) |
| CDR SUM | 1.5 (0.7)b | 1.3 (0.7)c | 0.0 (0.1) |
| Conversion to dementia over 5 years (%) | 0 (0) | 5 (12.5)c | 2 (2.6) |
Significant differences between: a) SNAP/L- and SNAP/L+; b) SNAP/L- and A- CN group; c) SNAP/L+ and A- CN group ⁎p < 0.10; ◊ z-score. Results reported in the table are not corrected for age, gender and education (for the cognitive tasks), see the Results section for corrected results.
SNAP = suspected non-AD pathology; L−/+ = neurodegeneration negative/positive as defined by a longitudinal measure; A- = amyloid negative; CN = cognitively normal; HV = hippocampal volume; FDG-PET = Fludeoxyglucose Postron Emission Tomography; SPARE-AD = Spatial Pattern of Abnormality for Recognition of Early Alzheimer's Disease; SUVR = standardized uptake value ratio; CSF = cerebrospinal fluid; WMH = white matter hyperintensity; MMSE = Mini Mental Status Examination; TMT = Trail Making Test; CDR = Clinical Dementia Rating.