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. 2018 Feb 12;5:6. doi: 10.3389/fnut.2018.00006

Table 2.

Parameters (mean ± SEM, n = 9 for all parameters except eRTw and sTw TMS where n = 7) of the musculus vastus medialis (VM) function evaluated with electrical peripheral nerve (PNS) and transcranial magnetic (TMS) stimulation and before (PreEx) and after (PostEx) repeated knee extensor exercise to fatigue performed 1 h after ingestion of placebo or caffeine supplements.

Parameters Stimulus Placebo
Caffeine
PreEx PostEx PreEx PostEx
I. Resting muscle
potTw amplitude (% MVC)a PNS 24.7 ± 1.8 20.4 ± 2.1 24.4 ± 1.3 18.5 ± 1.5
eRTw (%MVC)a TMS 21.2 ± 6.5 17.6 ± 4.6 22.5 ± 5.0 16.1 ± 3.8

II. Knee extensors performing maximal voluntary isometric contraction (MVC)
Force (N)a 433.7 ± 25.6 376.0 ± 21.6 453.6 ± 12.5 402.0 ± 20.5
VM EMG MDF (Hz)a 81.3 ± 6.8 92.4 ± 9.1 87.5 ± 8.0 94.2 ± 7.4
VM EMG RMS amplitude (mV)a 0.22 ± 0.03 0.18 ± 0.01 0.21 ± 0.03 0.15 ± 0.02
VM EMG RMS amplitude (%Mmax)c 4.04 ± 0.71 4.68 ± 1.09 4.84 ± 0.64 3.82 ± 0.72
sTw amplitude (% MVC)b PNS 3.7 ± 1.1 3.7 ± 0.9 2.5 ± 0.5 2.1 ± 0.5
sTw amplitude (% MVC) TMS 2.3 ± 0.6 2.0 ± 0.7 1.2 ± 0.3 1.7 ± 0.4
CT (ms)b PNS 29.3 ± 3.8 29.9 ± 3.4 23.6 ± 2.3 24.9 ± 2.9
CT (ms) TMS 26.5 ± 3.2 21.4 ± 0.4 17.3 ± 2.3 18.3 ± 2.7
HRT (ms) PNS 17.5 ± 0.8 17.4 ± 1.9 17.0 ± 1.1 15.3 ± 1.7
RR (1 s−1)a,b TMS −11.4 ± 1.0 −12.1 ± 1.3 −12.5 ± 0.9 −14.9 ± 0.9
VM CSP (ms) TMS 201.5 ± 17.3 201.3 ± 15.4 210.3 ± 16.8 209.5 ± 22.1

potTw, potentiated twitch; sTw, twitch superimposed during MVC; eRTw, estimated resting twitch; MDF, median frequency of the EMG power spectral density; Mmax, maximal M-wave amplitude; CT, twitch contraction time; HRT, twitch half relaxation time; RR, twitch relaxation rate; CSP, cortical silent period.

aMain time effect.

bMain condition effect.

cInteraction effect.