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Effects of acute systemic administration of DL77 on exploratory behavior in EPM. DL77 (5 mg/kg) did not alter the percentage of time spent on the open arms of the EPM (A), increase the number of entries into the open arms (B) and the percentage of entries into the open arms (C). Acute systemic pretreatment with the H3R antagonist/inverse agonist DL77 (5 mg/kg, i.p.) did not affect the number of closed arm entries (D). Data are expressed as mean ± SEM (n = 6).
