Table 2.
Sequence motifs of the pockets P1 and P2 of characterized CDPSs, colored according to the aminoacyl mainly accommodated* (inferred from sequence alignments and proximity with characterized CDPSs or enzymes synthesizing homo-cyclodipeptides).
| Pocket P1 | Pocket P2 | |||
|---|---|---|---|---|
| CDPS | Amino acyl mainly accommodated | Sequence motifs | Amino acyl mainly accommodated | Sequence motifs |
 | ||||
| Y | VGITMLFN | Y | LRFDQLP | |
| Y | VGVTMLFN | Y | LAYSQLP | |
| Y | VGITMLFN | Y | LAFSQLP | |
| Y | VGVTMLFN | Y | LSFEQLP | |
| F | VGITMFFV | Y | MHFGVTP | |
| F | LGVAIFLC | Y | HFVGKLP | |
| F | LGVVLFFT | F/M | QDFDKMP | |
| F | LGLVLFLT | L | QALEKMP | |
| W | LGVALFLS | L | MSFGMAQ | |
| W | LGVALFFA | W | MLHGVMP | |
| W | LGVALFFA | W | MGFAEPL | |
| W | LGVALFFH | W | MQFKTLA | |
| W | LGIALFFS | Y | MLHGLTP | |
| W | LGVALFFS | Y | MTFPQIP | |
| W | LGIPLFFV | P/A | VRARAGF | |
| W | LGIPLFFV | P | ARAVMVP | |
| W | LGVPLLLA | P | ASVGKID | |
| P | CGHPWLLY | P | TDVHRIP | |
| P | LGFPWFMF | L | LKAGQFE | |
| P | VGLPWFFF | R | ATAGRIS | |
| P | LGLPWLFF | M | NQCNSFR | |
| L | LGFPWLVF | V/L/I | TGARRMD | |
| F/G ? | LGLAWIGC | F/G ? | VAYHRLA | |
| F/I ? | LGLPWFLF | F/I ? | IRVTRSP | |
| C | VGYPSIFF | G/C | SAIKDPT | |
| L/I ? | FGLGCVFM | L/I ? | FRYRGFS | |
| L/I ? | FGLGCIFF | L/I ? | FSYRGFG | |
| G | LFVAWIVI | E | NTYRKLT | |
| A/P ? | FAYVHAVN | A/P ? | FFYRGID | |
| H | GAYAWELY | P/E | FEWKYTR | |
| F | FGLAWSLL | F/Y | LNYSTYA | |
| Y | FPLCWISE | Y | LKLRREE | |
*
Orange: Y, blue: F, green: W, yellow: P, violet: L. When accommodation in P1 or P2 could not be deduced from existing data, amino acyl accommodated are indicated in both pockets and signaled by a question mark. Groups of CDPSs phylogenetically close are framed. NYH CDPSs previously grouped in the same specificity group than AlbC are labeled in blue.