Table 2.

Crude and adjusted AUROCs for discrimination characteristics of SIRS, SOFA, PELOD-2 and qSOFA on ICU admission in patients < 18 years with suspected or confirmed infection

Predictor	Definition	Primary outcome: Hospital mortality		Secondary outcome: mortality and/or ICU LOS ≥ 3 days
		Area under the curve		Area under the curve
		Crude	Adjusted	Crude	Adjusted
SIRS	SIRS N criteria	0.630 (0.583–0.676)	0.727 (0.682–0.772)	0.603 (0.580–0.626)	0.676 (0.654–0.699)
	SIRS ≥ 2 criteria (paediatric)	0.559 (0.528–0.591)	0.710 (0.664–0.756)	0.551 (0.533–0.568)	0.664 (0.641–0.687)
	SIRS ≥ 2 criteria (any)	0.563 (0.532–0.594)	0.708 (0.664–0.751)	0.565 (0.548–0.582)	0.673 (0.652–0.694)
Severe sepsis	2005 consensus	0.586 (0.550–0.622)	0.711 (0.667–0.755)	0.592 (0.574–0.611)	0.677 (0.656–0.698)
SOFA	SOFA score	0.782 (0.738–0.827)	0.829 (0.791–0.868)	0.731 (0.710–0.752)	0.751 (0.730–0.772)
	SOFA ≥ 2 criteria	0.595 (0.571–0.620)	0.743 (0.701–0.785)	0.615 (0.599–0.631)	0.702 (0.689–0.723)
PELOD	PELOD score	0.774 (0.731–0.818)	0.816 (0.777–0.854)	0.750 (0.730–0.770)	0.771 (0.752–0.790)
	PELOD ≥ 2 criteria	0.601 (0.578–0.625)	0.726 (0.685–0.767)	0.613 (0.597–0.629)	0.694 (0.673–0.715)
	PELOD ≥ 8 criteria	0.719 (0.679–0.759)	0.812 (0.774–0.851)	0.633 (0.618–0.649)	0.744 (0.724–0.764)
qSOFA	qSOFA score	0.638 (0.588–0.687)	0.739 (0.695–0.784)	0.597 (0.575–0.620)	0.682 (0.659–0.704)
	qSOFA ≥ 2 criteria	0.591 (0.552–0.631)	0.722 (0.677–0.767)	0.581 (0.560–0.601)	0.679 (0.656–0.701)

Predictor	Definition	Primary outcome: hospital mortality
		Sensitivity (%)	Specificity (%)	Negative predictive value (%)	Positive predictive value (%)
SIRS	SIRS ≥ 2 criteria (pediatric)	84.9	27.0	96.5	7.0
SIRS	SIRS ≥ 2 criteria (any)	83.4	29.1	96.6	6.8
Severe sepsis	2005 consensus	74.5	42.7	96.5	7.4
SOFA	SOFA ≥ 2 criteria	92.1	26.9	98.1	7.6
qSOFA	qSOFA ≥ 2 criteria	70.3	48.0	96.1	8.1
PELOD	PELOD ≥ 2 criteria	91.9	28.3	98.3	7.3
PELOD	PELOD ≥ 8 criteria	88.1	55.7	97.0	22.2