Table 2.
Associations between MSK1 protein expression and clinicopathologic variables
| Variables | MSK1 (n = 1270) | ||
|---|---|---|---|
| Low expression | High expression | P-value | |
| Age (years) | |||
| ≤ 40 years | 49 (3.9%) | 74 (5.8%) | 0.004 |
| > 40 years | 315 (24.8%) | 831 (65.5%) | |
| Tumour size (mm) | |||
| ≤ 20 mm | 207 (16.4%) | 545 (43.0%) | 0.275 |
| > 20 mm | 156 (12.3%) | 358 (28.3%) | |
| Tumour stage | |||
| I | 227 (17.9%) | 540 (42.7%) | 0.544 |
| II | 105 (8.3%) | 275 (21.7%) | |
| III | 30 (2.4%) | 89 (7.0%) | |
| Tumour grade | |||
| I | 38 (3.0%) | 169 (13.3%) | < 0.001 |
| II | 96 (7.6%) | 326 (25.8%) | |
| III | 229 (18.1%) | 408 (32.2%) | |
| Nottingham prognostic index | |||
| ≤ 3.4 | 85 (6.7%) | 290 (22.9%) | 0.007 |
| 3.41–5.4 | 198 (15.7%) | 451 (35.7%) | |
| > 5.4 | 79 (6.3%) | 161 (12.7%) | |
| Lymphovascular invasion | |||
| Positive | 107 (10.1%) | 248 (23.4%) | 0.263 |
| Negative | 190 (17.9%) | 517 (48.7%) | |
| Operation type | |||
| Mastectomy | 213 (16.9%) | 520 (41.3%) | 0.682 |
| WLE Lumpectomy | 147 (11.7%) | 378 (30.0%) | |
| ER status | |||
| Positive | 205 (16.7%) | 704 (57.2%) | < 0.001 |
| Negative | 139 (11.3%) | 183 (14.9%) | |
| PR status | |||
| Positive | 147 (12.3%) | 538 (45.0%) | < 0.001 |
| Negative | 196 (16.4%) | 314 (26.3%) | |
| HER2 status | |||
| Positive | 49 (3.9%) | 125 (10.1%) | 0.894 |
| Negative | 306 (24.6%) | 762 (61.4%) | |
| Basal-like status | |||
| Positive | 96 (8.1%) | 153 (13.0%) | < 0.001 |
| Negative | 247 (20.9%) | 685 (58.0%) | |
| Triple-negative status | |||
| Positive | 104 (8.5%) | 109 (8.9%) | < 0.001 |
| Negative | 237 (19.4%) | 774 (63.2%) | |
| Breast cancer-specific survival | |||
| Alive | 577 (41.7%) | 342 (24.7%) | 0.01 |
| Dead | 259 (18.7%) | 207 (14.9%) | |
| Recurrence | |||
| Present | 167 (13.5%) | 362 (29.3%) | 0.013 |
| Not present | 178 (14.4%) | 530 (42.8%) | |
| Distant metastasis | |||
| Present | 138 (11.0%) | 267 (21.2%) | 0.002 |
| Not present | 220 (17.5%) | 635 (50.4%) | |
Correlations between MSK1 protein expression and clinicopathologic variables was assessed using Pearson’s Ch-square test of association (χ2) or Fisher’s exact test if in a 2 × 2 tables and cell count was less than 5. Significant P values are indicated by bold font
ER oestrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2