Fig. 5.

Early postnatal deletion of Arl13b causes cystic kidneys, whereas later postnatal deletion shows no global negative side effects. (A and A′) H&E staining of kidneys from p51 WT and Arl13b^flox/flox; CAGG-CreER ΔP4 shows that early postnatal deletion of Arl13b results in severely cystic kidneys in adulthood. (B and B′) H&E staining of sagittal sections from p51 Arl13b^flox/flox and Arl13b^flox/flox; CAGG-CreER ΔP4 cerebella shows normal foliation in both. (C and C′) H&E staining of kidneys from p60 WT and Arl13b^flox/flox; CAGG-CreER ΔP14 shows that later postnatal deletion of Arl13b at P14 results in grossly normal kidneys. (D and D′) H&E staining of sagittal sections from p60 Arl13b^flox/flox and Arl13b^flox/flox; CAGG-CreER ΔP14 cerebella shows normal foliation in both. (Scale bar, 1 mm.)