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. 2018 Jan 22;115(7):1646–1651. doi: 10.1073/pnas.1714760115

Fig. 4.

Fig. 4.

Effects of SsTx on vascular contractility of thoracic aortas. Representative vascular contractility of thoracic aorta when challenged sequentially with (A) CV, PE, and ACh; (B) CV-Sf, PE, and ACh; (C) 1 and 5 μM SsTx, PE, and ACh; (D) 10 mg/mL CV and 40 μM RTG; and (E) 5 μM SsTx and 40 μM RTG. (F) Concentration–response curves of current increases at different concentrations of RTG in the presence of 5 μM SsTx. The smooth curve was a fitting of data points to the Hill equation. The average EC50 value is 7.83 ± 0.12 μM (n = 6 cells per data point). Increased currents from that in the presence of 5 μM SsTx were normalized by the increased currents in the presence of saturated RTG. CV, crude venom; PE, phenylephrine; RTG, retigabine.