Fig. 6.

OLT1177 reduces muscle oxidative stress and increases oxidative metabolism in vivo. Metabolomic analyses were performed on muscle 2 h following LPS challenge from mice treated with OLT1177 or vehicle. Mean ± SEM in arbitrary units (AU) for reduced glutathione (GSH) (A); oxidized glutathione (GSSG) (B); GSH/GSSG ratios (C); ribose phosphate (D); ATP (E); and total adenylate pool (F); α-ketoglutarate (G); citrate (H); oxaloacetate (I); and succinate (J). n = 3 mice per group. **P < 0.01, *P < 0.05.