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OLT1177 reduces phosphorylation of NF-κB. (A–D) Mean ± SEM of NF-κB, IκB, IKK, and IRAK4 phosphorylation measured in fresh CD11b+CD3− spleen-derived cells from mice treated with saline (vehicle) or OLT1177 under steady-state conditions. (E–H) Mean ± SEM of NF-κB, IκB, IKK, and IRAK4 phosphorylation measured in CD11b+CD3− spleen-derived cells from mice treated with saline (vehicle) or OLT1177 stimulated for 30 min with LPS. n = 3 mice per group. **P < 0.01, *P < 0.05.
