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. 2018 Jan 30;115(7):E1511–E1519. doi: 10.1073/pnas.1716452115

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Fig. 2. — Loss of Cic in hematopoietic cells causes T cell acute lymphoblastic leukemia/lymphoma (T-ALL). (A) Tumor-free survival for Tek-cre; Cic^flox/flox mice and control mice. The median survival age was 49.2 wk for the Tek-cre; Cic^flox/flox mice. (B) In the bone marrow transplantation study, wild-type mice that received donor cells from the UBC-cre/ERT2; Cic^flox/flox mice and treated with tamoxifen (TAM) showed reduced tumor-free survival (median survival = 26.6 wk posttamoxifen treatment). (C) Flow cytometry analysis of the thymus from wild-type mice received donor cells from the control Cic^flox/flox mice, and tumors from two wild-type mice received donor cells from the UBC-cre/ERT2; Cic^flox/flox mice. Upper panels depict percentage of donor-derived cells (CD45.2⁺).