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Defective ubiquitylation of histone H2A in C. elegans model of RING1 p.R95Q. (Left) Immunoblot analysis of acid-extracted histones from wild-type larvae (WT) or larvae carrying the SPAT-3 (R209Q), knockout (KO) or partial deletion (DEL) mutations. (Right) Levels of ubiquitylated histone H2A (H2A-Ub1) relative to H2A were quantified from two independent experiments.
