Table 2.

Gut scoring matrix (maximum 29)

Feature	Score	Description
Colon
Crypt architecture	0	Normal
	1	Irregular
	2	Moderate crypt loss (10–50%)
	3	Severe crypt loss (50–90%)
	4	Small/medium ulcers (< 10 crypt widths)
	5	Large ulcers (> 10 crypt widths)
Crypt abscesses	0	None
	1	1–5
	2	6–10
	3	> 10
Crypt length (medial colon)	0	< 250 μm
	1	250–300 μm
	2	300–350 μm
	3	350–400 μm
	4	> 400 μm
Tissue damage	0	No damage
	1	Discrete lesions
	2	Mucosal erosions
	3	Extensive mucosal damage
Inflammatory cell infiltration	0	Occasional infiltration
	1	Increasing leukocytes in lamina propria
	2	Confluence of leukocytes extending to submucosa
	3	Transmural extension of inflammatory infiltrates
Lamina propria neutrophils (PMN)	0	0–5 PMNs/HPF
	1	6–10 PMNs/HPF
	2	11–20 PMNs/HPF
	3	> 20 PMNs/HPF
Ileum
Inflammatory cell infiltration	0	Occasional infiltration
	1	Increasing leukocytes in lamina propria
	2	Confluence of leukocytes extending to submucosa
	3	Transmural extension of inflammatory infiltrates
Lamina propria neutrophils (PMN)	0	0–5 PMNs/HPF
	1	6–10 PMNs/HPF
	2	11–20 PMNs/HPF
	3	> 20 PMNs/HPF
Paneth cell	0	Normal: small, densely packed granules
	1	Irregular: less granules
	2	Abnormal: less granules, large vacuolar spaces