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. 2018 Feb 17;17:59. doi: 10.1186/s12943-018-0773-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — β-catenin is expressed in primary human melanomas in particular in cells of the invasive front. a Cytoplasmic expression of β-catenin in primary melanomas. A stronger expression of β-catenin in melanoma cells of the invasive front was observed by immunohistochemistry when compared to the bulk cells of the primary melanoma. Melanoma cells of the invasive front with a high expression of β-catenin had a spindle-like, mesenchymal morphology. Overview (upper row) and higher magnification of the invasive front (lower row) of four representative primary melanomas. b Overall survival (OS) analysis of the TCGA data set for the top and bottom (n = 50 each) WNT3A and WNT5A expressing melanomas reveal a significantly worse OS for WNT3A-high (p = 0.03) but not WNT5A-high melanoma patients (p = 0.39)