Table 2.
Genotypic and allelic frequencies of the DOCK7-ANGPTL3 SNPs in controls and cases
| SNP/Genotype/Allele | Control (%) | CAD (%) | IS (%) | P CAD | P IS |
|---|---|---|---|---|---|
| Rs1748195 | |||||
| CC | 361 (58.1) | 303 (53.3) | 311 (57.7) | ||
| CG | 227 (36.6) | 216 (38.0) | 188 (34.9) | ||
| GG | 33 (5.3) | 49 (8.7) | 40 (7.4) | 0.047 | 0.321 |
| C | 949 (76.4) | 822 (72.4) | 810 (75.1) | ||
| G | 293 (23.6) | 314 (27.6) | 268 (24.9) | 0.024 | 0.476 |
| PHWE | 0.728 | 0.240 | 0.123 | ||
| CC/CG | 588 (94.7) | 519 (91.3) | 499 (92.6) | ||
| GG | 33 (5.3) | 49 (8.7) | 40 (7.4) | 0.024 | 0.140 |
| Rs12563308 | |||||
| TT | 534 (86.0) | 517 (91.0) | 479 (88.8) | ||
| CT | 84 (13.5) | 48 (8.5) | 57 (10.6) | ||
| CC | 3 (0.5) | 3 (0.5) | 3 (0.6) | 0.021 | 0.305 |
| T | 1152 (92.8) | 1082 (95.2) | 1015 (94.2) | ||
| C | 80 (7.2) | 54 (4.8) | 63 (5.8) | 0.067 | 0.518 |
| PHWE | 0.876 | 0.112 | 0.364 | ||
| TT | 534 (86.0) | 517 (91.0) | 479 (88.8) | ||
| CT/CC | 87 (14.0) | 51 (9.0) | 60 (11.2) | 0.007 | 0.142 |
SNP single nucleotide polymorphisms, CAD coronary artery disease, IS ischemic disease, HWE Hardy- Weinberg equilibrium, PHWE the P value of the Hardy-Weinberg equilibrium, PCAD the P value between CAD patients and controls, PIS the P value between IS patients and controls