Table 2.

Ability of mesothelin to predict radiological progression depending on cut-off used and radiological reporting method

Mesothelin Cut-off	10%		15%		25%
CT reporting method	Clinically reported CT	MRECIST	Clinically reported CT	MRECIST	Clinically reported CT	MRECIST
No.	43	25	43	25	43	25
Sensitivity	95.8 (78.8–99.8)	90.9 (58.7–99.7)	83.3 (62.6–95.3)	72.7 (39.0–93.9)	80.0 (59.3–93.2)	72.7 (39.0–93.9)
Specificity	73.7 (48.8–90.8)	57.1 (28.9–82.3)	84.2 (60.4–96.6)	71.4 (41.9–91.6)	84.2 (60.4–96.6)	71.4 (41.9–91.6)
PPV	82.1 (68.3–90.8)	62.5 (46.9–75.8)	87.0 (69.9–95.0)	66.7 (44.7–83.2)	87.0 (69.9–95.0)	66.7 (44.7–83.2)
NPV	93.3 (66.8–99.0)	88.9 (53.9–98.2)	80 (61.7–90.9)	76.9 (54.6–90.2)	76.2 (58.8–87.8)	76.9 (54.6–90.2)
Accuracy	86.0%		83.7%		0.81%