Table 2.

Perioperative details of the included studies

Author	Year	Intervention	Prosthesis properties	Approach	Transfusion protocol	Thromboprophylaxis
Gillespie [20]	2015	TXA: 2 g in 100 ml NS for 5 min Placebo: 100 ml NS for 5 min	N/S	DP	1) Hb < 7.0 g/dl 2) 7.1 g/dl < Hb < 9.0 g/dl + symptoms	N/S
Pauzenberger [23]	2017	TXA: 1 g TXA intravenously in 100 ml NS, 2 doses Placebo: 100 ml NS, 2 doses	TSA (Eclipse; Arthrex Inc., Naples, Florida) RTSA (Delta Xtend; DePuy Synthes, Warsaw, Indiana)	DP	1) Hb < 8 g/dl 2) 8 g/dl < Hb < 10 g/dl + symptoms	Chemical prophylaxis (subcutaneous 40 mg of enoxaparin sodium + aspirin)
Vara [34]	2017	TXA: 10 mg/kg IV, 1st dose within 60 mins before surgery, 2nd dose at wound closure Placebo: NS	102 Non-cemented RTSA (79 Zimmer; 11 DePuy; 4 Biomet; 2 Encore,)	DP	1) Hb < 7 g/dl 2) 7 g/dl < Hb < 9 g/dl + symptoms	Chemical prophylaxis (subcutaneous heparin + oral aspirin) Mechanical prophylaxis (compression stockings)
Abildgaard [33]	2016	TXA: 1 g IV at skin preparation Placebo: no TXA	TSA (Bigliani/ Flatow Anatomical Total Shoulder; Zimmer, Warsaw, IN, USA) RTSA (Trabecular Metal Inverse/Reverse Total Shoulder, Zimmer)	DP	1) Hb < 7 g/dl 2) 7 g/dl < Hb < 9 g/dl + symptoms	Chemical prophylaxis was not routinely used postoperatively
Friedman [19]	2016	TXA: 20 mg/kg IV at skin preparation Placebo: no TXA	RTSA: cemented; brand N/S TSA: 90% non-cemented;	N/S	N/S	N/S
Kim [24]	2017	TXA: 500 mg IV	25 DJO Reverse Shoulder Prosthesis; 16 Tornier reverse shoulder prosthesis; 7 Biomet Comprehensive Reverse Total Shoulder Replacement	DP	No absolute guideline	N/S

DP Deltopectoral approach; Hb Hemoglobin; IV Intravenous; NS Normal saline; N/S Not shown; RTSA Reverse total shoulder arthroplasty; TSA Total shoulder arthroplasty; TXA Tranexamic acid