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. 2018 Feb 16;8:3150. doi: 10.1038/s41598-018-20874-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan-Meier curves for composite cardiovascular and renal events during the follow-up period in patients with eGFR of <45 ml/min per 1.73 m² and/or UACR of ≥300 mg/g creatinine (a) and the other patients (b). In (a), the numbers of patients in ARB and non-ARB groups were 96 and 91, respectively, and the number of occurrence of endpoints was 11 and 22 in ARB group and non-ARB group, respectively. In (b), the number of endpoints was 27 in 516 patients assigned ARB group and 29 in 518 patients assigned non-ARB group. Abbreviations: G3b and/or A3, patients with estimated glomerular filtration rate of <45 ml/min per 1.73 m² and/or urinary albumin/creatinine ratio of ≥300 mg/g creatinine; The other, patients with both estimated glomerular filtration rate of ≥45 ml/min per 1.73 m² and urinary albumin/creatinine ratio of <300 mg/g creatinine; ARB, antihypertensive treatment with angiotensin II receptor blocker; Non-ARB, treatment with antihypertensive drugs except for angiotensin II receptor blocker; HR, hazard ratio; 95%CI, 95% confidence interval.